Semantic network function captured by word frequency in nondemented APOE ε4 carriers.
نویسندگان
چکیده
منابع مشابه
Frequency Specific Effects of ApoE ε4 Allele on Resting-State Networks in Nondemented Elders
We applied resting-state functional magnetic resonance imaging (fMRI) to examine the Apolipoprotein E (ApoE) ε4 allele effects on functional connectivity of the default mode network (DMN) and the salience network (SN). Considering the frequency specific effects of functional connectivity, we decomposed the brain network time courses into two bands: 0.01-0.027 Hz and 0.027-0.08 Hz. All scans wer...
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APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network analysis to identify specific co-expression modules in AD based on APOE ε4 stratification. Two specific module...
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BACKGROUND Prospective and case-control studies have demonstrated that memory loss and executive dysfunction occur early in Alzheimer disease (AD). OBJECTIVE To investigate these observations by the study of persons at risk for autosomal dominant forms of AD. METHODS Neuropsychological and genetic tests were performed on 51 nondemented at-risk members of 10 Mexican families with two distinc...
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ژورنال
عنوان ژورنال: Neuropsychology
سال: 2019
ISSN: 1931-1559,0894-4105
DOI: 10.1037/neu0000508